- 保存条件：
Room temp. (continental US) or gel packs
- 保质期：
Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
- 英文名：
AG-14361
- 数量：
1
- 供应商：
BPS Bioscience Inc.
- CAS号：
/
- 规格：
5 mg
AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strａnd breaks.
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