PROTAC® Optimization Kit for CDK Kinase-Cereblon Binding

保存条件：-80°C英文名：PROTAC®OptimizationKitforCDKKinase-CereblonBinding数量：1供应商：BPSBioscienceInc

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更新时间：2024-11-24

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品牌	BPS Bioscience

保存条件：
-80°C
英文名：
PROTAC® Optimization Kit for CDK Kinase-Cereblon Binding
数量：
1
供应商：
BPS Bioscience Inc.
CAS号：
/
规格：
盒

The PROTAC Optimization Kit for CDK Kinase-Cereblon Binding is designed for testing and profiling of PROTACs directed against the CDK Kinase family and Cereblon. Cereblon (CRBN) is a Substrate recognition component of the DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

The CDK inhibitor Palbociclib is included as a control inhibitor of PROTAC binding to CDK. With this kit, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and CDK4 or CDK6 Kinase. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.

温馨提示：不可用于临床治疗。

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PROTAC® Optimization Kit for CDK Kinase-Cereblon Binding

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