- 数量：
1
- 供应商：
BPS Bioscience
- 细胞类型：
稳转细胞系
- 品系：
Jurkat (clone E6-1), human T lymphoblast, suspension
- 组织来源：
/
- 相关疾病：
多种
- 物种来源：
human
- 免疫类型：
多种
- 器官来源：
无
- 运输方式：
干冰
- 年限：
10
- 生长状态：
良好
- CAS号：
无
- 英文名：
TCR/B2M Knockout NFAT Luciferase Reporter Jurkat Cell Line
- 注册证号：
/
- 规格：
2管
This cell line is a double knockout of TCR (T Cell Receptor) and B2M (Beta-2-Microglobulin). First, the TRAC (T-Cell Receptor Alpha Constant) and the TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα/β chains were genetically removed by CRISPR/Cas9 genome editing from NFAT Luciferase Reporter Jurkat cells to generate the TCR Knockout NFAT Luciferase Reporter Jurkat cell Line (BPS Bioscience #78556). These TCR knockout cells were used to generate a new cell line in which B2M was also genetically removed by CRISPR/Cas9 genome editing. Expression of the firefly luciferase gene is driven by NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway in these cells can be monitored by measuring luciferase activity.
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