GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

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更新时间：2024-11-24

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详细介绍

品牌	BPS Bioscience

数量：
1
供应商：
BPS Bioscience
细胞类型：
稳转细胞系
品系：
HeLa
组织来源：
/
相关疾病：
多种
物种来源：
human
免疫类型：
多种
器官来源：
无
运输方式：
干冰
年限：
10
生长状态：
良好
CAS号：
无
英文名：
GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)
注册证号：
/
规格：
2管

The GAS reporter (Luc)-HeLa cell line is designed to monitor the activity of interferon gamma-induced signal transduction pathways in cultured cells by measuring activated STAT1 homodimers. It contains a firefly luciferase gene driven by three copies of the interferon gamma-activated sites (GAS) located upstream of the minimal TATA promoter. IFNγ first binds to a heterodimeric receptor consisting of two chains, IFNGR1 and IFNGR2, causing its dimerization and the activation of specific Janus family kinases (JAK1 and JAK2). Two STAT1 molecules associate with this ligand-activated receptor complex and are activated by phosphorylation to form active homodimer. The active STAT1 homodimers translocate to the nucleus where they bind interferon gamma-activated sites (GAS) in the promoter of IFNγ inducible genes, including luciferase reporter gene.

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GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

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