IRF Reporter (Luc) - THP-1 Cell line (cGAS-Sting Signaling Pathway)

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更新时间：2024-11-24

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详细介绍

品牌	BPS Bioscience

数量：
1
供应商：
BPS Bioscience
细胞类型：
稳转细胞系
品系：
THP-1
组织来源：
/
相关疾病：
多种
物种来源：
human
免疫类型：
多种
器官来源：
无
运输方式：
干冰
年限：
10
生长状态：
良好
CAS号：
无
英文名：
IRF Reporter (Luc) - THP-1 Cell line (cGAS-Sting Signaling Pathway)
注册证号：
/
规格：
2管

The Interferon Regulatory Factor (IRF) reporter (Luc)-THP-1 cell line is designed to study the activation and signaling of Cytosolic DNA Sensors (CDS) in human monocytic cell line THP-1. It contains a firefly luciferase gene driven by multimerized ISRE (Interferon Stimulated Response Element) located upstream of the minimal TATA promoter. The cGAS-STING pathway acts to detect cytosolic DNA and induce an immune response. Briefly, upon binding DNA, the protein cGAS (cyclic GMP-AMP Synthase) triggers reaction of GTP and ATP to form cGAMP. cGAMP binds to STING (Stimulator of Interferon Genes) which triggers phosphorylation of IRF3 via TBK1. IRF3 can then bind to interferon-stimulated responsive elements (ISRE) in the nucleus and leads to IFN-α/β production. The IRF reporter (Luc)-THP-1 cell line is highly responsive to STING and CDS ligands.

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IRF Reporter (Luc) - THP-1 Cell line (cGAS-Sting Signaling Pathway)

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