b-AP15 (NSC-687852)

产品型号：27701-2

更新时间：2024-11-25

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详细介绍

品牌	BPS Bioscience

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Description

Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.

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Synonyms

b–AP15, NSC–687852, 3,5–Bis[(4–nitrophenyl)methylene]–1?–(1–oxo–2–propene–1–yl)–4–piperidone

上一篇：27606-2AZD2461

下一篇：27606-1AZD2461

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b-AP15 (NSC-687852)

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