(-)-JQ1

●Purchase●Description(-)-JQ1istheinactivestereoisomerofthepotent,cell-permeable,smallmoleculebromodomaininhibitor(+)-JQ1thatcompetitivelybindstoacetyl-lysinerecognitionmotifs

产品型号：27335

更新时间：2024-11-26

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品牌	BPS Bioscience

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Description

(-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM.

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Synonyms

(R)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

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