TL1A-Responsive Luciferase Reporter Jurkat Cell Line

TNF-like ligａnd 1A (TL1A)-Responsive Luciferase Reporter Jurkat Cell Line is a TL1A-responsive DR3/NF-kB luciferase reporter Jurkat cell line expressing firefly luciferase under the control of an NF-kB response element, and with stable expression of human DR3 (death receptor 3; TNFRSF25; NM_003790.3). Expression of the firefly luciferase gene is driven by NF-kB response elements located upstream of the minimal TATA promoter. Activation of the NF-kB signaling pathway by the DR3 ligａnd TL1A (TNF-like Protein 1A; TNFSF15) can be monitored by measuring luciferase activity.

This cell line has been validated to be responsive to TL1A and TNF-α stimulation. TL1A stimulation was blocked by the neutralizing anti-TL1A antibody (BPS Bioscience #101729).

Figure 1: Schematic representation of the TL1A response in TL1A Responsive Luciferase Reporter Jurkat Cell Line.

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