NF- κB Reporter (Luc) – THP-1 Cell Line

The NF-κB reporter (Luc)-THP-1 cell line is designed for monitoring NF-κB (nuclear factor κB) signal transduction pathways. It contains a firefly luciferase gene driven by four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or NOD agonists, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.