Hippo Pathway/TEAD Luciferase Reporter MCF7 Cell Line

The TEAD Luciferase Reporter MCF7 cell line contains the firefly luciferase gene under the control of TEAD responsive elements stably integrated into the human breast cancer cell line MCF7. When the Hippo pathway is not stimulated, transcriptional coactivators YAP (Yes-associated protein) and TAZ (also known as WWTR1, WW domain containing transcription regulator 1) are localized in the nucleus and induce constitutive expression of the luciferase reporter. The cell line has been validated for the inhibition of the luciferase reporter by activators of the Hippo pathway, and for the activation of the luciferase reporter by inhibitors of the Hippo pathway.

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