● Description
Recombinant HEK293 cell line stably expressing full-length human calcitonin receptor-like receptor (CALCRL/CRLR/CLR; accession number: NM_005795) and firefly luciferase under the control of a multimerized cAMP response element (CRE). This cell line can be used to measure the EC50 and IC50 of CGRP receptor agonists and antagonists using luciferase reporter activity as read-out.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
● Synonyms
Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CRLR, CGRPR, LMPHM8, CALCRL, CLR
● Product Data Gallery
Cell surface expression of human CALCRL in CGRPR/CRE Luciferase Reporter HEK293 Cell Line.
Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the agonists α-CGRP and β-CGRP.
Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the small molecule antagonist Rimegepant.
Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the anti-CGRP Eptinezumab.
Dose response of CGRPR/CRE Luciferase Reporter HEK293 Cell Line to the anti-CGRP antibody Galcanezumab.
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