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P22077

●Purchase●DescriptionP22077isacellpermeableinhibitoroftheubiquitin-specificproteaseUSP7(IC50=8

产品型号:27712-1

更新时间:2024-11-28

  • 详细介绍
  • 品牌BPS Bioscience
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Description

P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 µM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50µM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20–40 µM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.

Synonyms
Ethanone, 1–[5–[(2,4–difluorophenyl)thio]–4–nitro–2–thienyl]–

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