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LDN-57444

●Purchase●DescriptionLDN-57444isacellpermeableubiquitinC-terminalhydrolase(UCH-L1)inhibitor(Ki=0

产品型号:27706-1

更新时间:2024-11-28

  • 详细介绍
  • 品牌BPS Bioscience
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Description

LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.

Synonyms
1H–Indole–2,3–dione, 5–chloro–1–[(2,5–dichlorophenyl)methyl]–, 3–(O–acetyloxime)

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