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首页>产品中心>>Ubiquitination>79575CBL-B TR-FRET Assay Kit

CBL-B TR-FRET Assay Kit

●Purchase●DescriptionHumanCasitasB-lineagelymphomaproto-oncogeneb(CBL-B)isanE3ubiquitin-proteinligasethatfunctionsasanegativeregulatorofT-cellactivation

产品型号：79575

更新时间：2024-11-28

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    • 品牌BPS Bioscience
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Description

Human Casitas B-lineage lymphoma proto-oncogene b (CBL-B) is an E3 ubiquitin-protein ligase that functions as a negative regulator of T-cell activation. It is a promising drug target in cancer immunotherapy. The CBL-B TR-FRET Assay Kit is designed to measure CBL-B auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes biotin-labeled Ubiquitin and a terbium-labeled antibody recognizing the GST-tagged CBL-B protein to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.

CBL-B TR-FRET

Figure: Illustration of Assay Principle

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Synonyms
UBE1, UBA1, ubcH5b, UBE2D2, E3 ubiquitin-protein ligase CBL-B, RING finger protein 56, CBL, CBLB, cbl TR-FRET
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